Defending champions Real Madrid crushed APOEL Nicosia 6-0 in Cyprus on Tuesday night.
Karim Benzema and Cristiano Ronaldo both scored twice for Madrid, while Luka Modric and Nacho also got on the scoresheet.
Liverpool threw away a three-goal lead to draw 3-3 at Sevilla.
Raheem Sterling struck late, as Manchester City beat Feyernoord 1-0 at the Etihad, while Napoli thrashed Shakhtar Donetsk 3-0 in Italy. Tottenham Hotspur fought back from a goal down, to win 2-1 against Borussia Dortmund at the Signal Iduna Park.
Spartak Moscow drew 1-1 with Maribor, while RB Leipzig defeated Monaco 4-1 in France.
Besiktas had earlier qualified for the roudnof 16, following a 1-1 draw at home with FC Porto.
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